A novel N-acetylglutamate synthase architecture revealed by the crystal structure of the bifunctional enzyme from Maricaulis maris.

Novel bifunctional N-acetylglutamate synthase/kinases (NAGS/K) that catalyze the first two steps of arginine biosynthesis and are homologous to vertebrate N-acetylglutamate synthase (NAGS), an essential cofactor-producing enzyme in the urea cycle, were identified in Maricaulis maris and several othe...

Full description

Bibliographic Details
Main Authors: Dashuang Shi, Yongdong Li, Juan Cabrera-Luque, Zhongmin Jin, Xiaolin Yu, Gengxiang Zhao, Nantaporn Haskins, Norma M Allewell, Mendel Tuchman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3236213?pdf=render