Novel <i>RB1</i> and <i>MET</i> Gene Mutations in a Case with Bilateral Retinoblastoma Followed by Multiple Metastatic Osteosarcoma

Novel <i>RB1</i> and <i>MET</i> Gene Mutations in a Case with Bilateral Retinoblastoma Followed by Multiple Metastatic Osteosarcoma

Retinoblastoma (Rb) is a malignant tumor of the developing retina that affects children before the age of five years in association with inherited or early germline mutations of the <i>RB1</i> gene. The genetic predisposition is also a driver for other primary malignancies, which have be...

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Bibliographic Details
Main Authors: Attila Mokánszki, Yi-Che Chang Chien, János András Mótyán, Péter Juhász, Emese Sarolta Bádon, László Madar, István Szegedi, Csongor Kiss, Gábor Méhes
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Diagnostics
Subjects:
retinoblastoma
osteosarcoma
<i>RB1</i> gene
<i>MET</i> gene
somatic mutations
next-generation sequencing (NGS)
Online Access:https://www.mdpi.com/2075-4418/11/1/28

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https://www.mdpi.com/2075-4418/11/1/28

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