High nucleosome occupancy is encoded at human regulatory sequences.

High nucleosome occupancy is encoded at human regulatory sequences.

Active eukaryotic regulatory sites are characterized by open chromatin, and yeast promoters and transcription factor binding sites (TFBSs) typically have low intrinsic nucleosome occupancy. Here, we show that in contrast to yeast, DNA at human promoters, enhancers, and TFBSs generally encodes high i...

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Bibliographic Details
Main Authors: Desiree Tillo, Noam Kaplan, Irene K Moore, Yvonne Fondufe-Mittendorf, Andrea J Gossett, Yair Field, Jason D Lieb, Jonathan Widom, Eran Segal, Timothy R Hughes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2817738?pdf=render

Internet

http://europepmc.org/articles/PMC2817738?pdf=render

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