Resolvin D5 Inhibits Neuropathic and Inflammatory Pain in Male But Not Female Mice: Distinct Actions of D-Series Resolvins in Chemotherapy-Induced Peripheral Neuropathy

Resolvin D5 Inhibits Neuropathic and Inflammatory Pain in Male But Not Female Mice: Distinct Actions of D-Series Resolvins in Chemotherapy-Induced Peripheral Neuropathy

Earlier studies have demonstrated that essential fatty acid-derived specialized pro-resolving mediators (SPMs) promote the resolution of inflammation and pain. However, the potential analgesic actions of SPMs in chemotherapy-induced peripheral neuropathy (CIPN) are not known. Recent results also sho...

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Bibliographic Details
Main Authors: Xin Luo, Yun Gu, Xueshu Tao, Charles Nicholas Serhan, Ru-Rong Ji
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Pharmacology
Subjects:
chemotherapy-induced peripheral neuropathy (CIPN)
docosahexaenoic acid (DHA)
intrathecal injection
neuropathic pain
resolvin D-series (RvDs)
sex dimorphism
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00745/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00745/full

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