Mucosal Autoimmunity to Cell-Bound GP2 Isoforms Is a Sensitive Marker in PSC and Associated With the Clinical Phenotype

Mucosal Autoimmunity to Cell-Bound GP2 Isoforms Is a Sensitive Marker in PSC and Associated With the Clinical Phenotype

Introduction: Zymogen granule glycoprotein 2 (GP2) was demonstrated as first autoimmune mucosal target in primary sclerosing cholangitis (PSC) associated with disease severity. Autoantibodies to four GP2 isoforms (aGP21−4) were found in patients with inflammatory bowel diseases but reactivity agains...

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Bibliographic Details
Main Authors: Mandy Sowa, Rafał Kolenda, Daniel C. Baumgart, Johann Pratschke, Maria Papp, Tamas Tornai, Jaroslaw Suchanski, Dimitrios P. Bogdanos, Maria G. Mytilinaiou, Jutta Hammermann, Martin W. Laass, Karsten Conrad, Christoph Schramm, Andre Franke, Dirk Roggenbuck, Peter Schierack
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
zymogen granule glycoprotein 2
primary sclerosing cholangitis
cirrhosis
cholangiocarcinoma
immunoglobulin A
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01959/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01959/full

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