Dynamic PET Measures of Tau Accumulation in Cognitively Normal Older Adults and Alzheimer's Disease Patients Measured Using [18F] THK-5351.

Dynamic PET Measures of Tau Accumulation in Cognitively Normal Older Adults and Alzheimer's Disease Patients Measured Using [18F] THK-5351.

[18F]THK5351, a recently-developed positron emission tomography (PET) tracer for measuring tau neurofibrillary tangle accumulation, may help researchers examine aging, disease, and tau pathology in living human brains. We examined THK5351 tracer pharmacokinetics to define an optimal acquisition time...

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Bibliographic Details
Main Authors: Samuel N Lockhart, Suzanne L Baker, Nobuyuki Okamura, Katsutoshi Furukawa, Aiko Ishiki, Shozo Furumoto, Manabu Tashiro, Kazuhiko Yanai, Hiroyuki Arai, Yukitsuka Kudo, Ryuichi Harada, Naoki Tomita, Kotaro Hiraoka, Shoichi Watanuki, William J Jagust
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4927104?pdf=render

Internet

http://europepmc.org/articles/PMC4927104?pdf=render

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