A phosphodiesterase 5 inhibitor, tadalafil, suppresses stromal predominance and inflammation in a rat model of nonbacterial prostatitis

A phosphodiesterase 5 inhibitor, tadalafil, suppresses stromal predominance and inflammation in a rat model of nonbacterial prostatitis

Abstract Background Chronic inflammation is thought to be a major causative factor for the development of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Tadalafil, a phosphodiesterase type 5 inhibitor (PDE5-I), which has been used for the treatment of BPH-LUTS in daily p...

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Bibliographic Details
Main Authors: Mikio Sugimoto, Xia Zhang, Nobufumi Ueda, Hiroyuki Tsunemori, Rikiya Taoka, Yusi Hayashida, Hiromi Hirama, Yasuyuki Miyauchi, Yuki Matsuoka, Hirohito Naito, Yu Osaki, Yosiyuki Kekehi
Format: Article
Language:English
Published: BMC 2019-10-01
Series:BMC Urology
Subjects:
Benign prostatic hyperplasia
Inflammatory cytokines
Lower urinary tract symptoms
Nonbacterial prostatitis
Tadalafil
Online Access:http://link.springer.com/article/10.1186/s12894-019-0525-x

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http://link.springer.com/article/10.1186/s12894-019-0525-x

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