MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation
The circadian clock and the cell cycle systems coordinate global physiology. Here the authors show that MYC represses the clock genes, together with MIZ1, and induces proliferation, suggesting that MYC inversely modulates cell cycle and circadian clock genes.
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2016-06-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11807 |
| id |
doaj-de2a1204a90241d887fa042addd3ea10 |
|---|---|
| record_format |
Article |
| spelling |
doaj-de2a1204a90241d887fa042addd3ea102021-05-11T11:11:58ZengNature Publishing GroupNature Communications2041-17232016-06-017111110.1038/ncomms11807MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferationAnton Shostak0Bianca Ruppert1Nati Ha2Philipp Bruns3Umut H. Toprak4ICGC MMML-Seq ProjectRoland Eils5Matthias Schlesner6Axel Diernfellner7Michael Brunner8Heidelberg University, Biochemistry CenterHeidelberg University, Biochemistry CenterHeidelberg University, Biochemistry CenterDivision Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ)Division Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ)Division Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ)Division Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ)Heidelberg University, Biochemistry CenterHeidelberg University, Biochemistry CenterThe circadian clock and the cell cycle systems coordinate global physiology. Here the authors show that MYC represses the clock genes, together with MIZ1, and induces proliferation, suggesting that MYC inversely modulates cell cycle and circadian clock genes.https://doi.org/10.1038/ncomms11807 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Anton Shostak Bianca Ruppert Nati Ha Philipp Bruns Umut H. Toprak ICGC MMML-Seq Project Roland Eils Matthias Schlesner Axel Diernfellner Michael Brunner |
| spellingShingle |
Anton Shostak Bianca Ruppert Nati Ha Philipp Bruns Umut H. Toprak ICGC MMML-Seq Project Roland Eils Matthias Schlesner Axel Diernfellner Michael Brunner MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation Nature Communications |
| author_facet |
Anton Shostak Bianca Ruppert Nati Ha Philipp Bruns Umut H. Toprak ICGC MMML-Seq Project Roland Eils Matthias Schlesner Axel Diernfellner Michael Brunner |
| author_sort |
Anton Shostak |
| title |
MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation |
| title_short |
MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation |
| title_full |
MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation |
| title_fullStr |
MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation |
| title_full_unstemmed |
MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation |
| title_sort |
myc/miz1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-06-01 |
| description |
The circadian clock and the cell cycle systems coordinate global physiology. Here the authors show that MYC represses the clock genes, together with MIZ1, and induces proliferation, suggesting that MYC inversely modulates cell cycle and circadian clock genes. |
| url |
https://doi.org/10.1038/ncomms11807 |
| work_keys_str_mv |
AT antonshostak mycmiz1dependentgenerepressioninverselycoordinatesthecircadianclockwithcellcycleandproliferation AT biancaruppert mycmiz1dependentgenerepressioninverselycoordinatesthecircadianclockwithcellcycleandproliferation AT natiha mycmiz1dependentgenerepressioninverselycoordinatesthecircadianclockwithcellcycleandproliferation AT philippbruns mycmiz1dependentgenerepressioninverselycoordinatesthecircadianclockwithcellcycleandproliferation AT umuthtoprak mycmiz1dependentgenerepressioninverselycoordinatesthecircadianclockwithcellcycleandproliferation AT icgcmmmlseqproject mycmiz1dependentgenerepressioninverselycoordinatesthecircadianclockwithcellcycleandproliferation AT rolandeils mycmiz1dependentgenerepressioninverselycoordinatesthecircadianclockwithcellcycleandproliferation AT matthiasschlesner mycmiz1dependentgenerepressioninverselycoordinatesthecircadianclockwithcellcycleandproliferation AT axeldiernfellner mycmiz1dependentgenerepressioninverselycoordinatesthecircadianclockwithcellcycleandproliferation AT michaelbrunner mycmiz1dependentgenerepressioninverselycoordinatesthecircadianclockwithcellcycleandproliferation |
| _version_ |
1721446909957111808 |