MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation

MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation

The circadian clock and the cell cycle systems coordinate global physiology. Here the authors show that MYC represses the clock genes, together with MIZ1, and induces proliferation, suggesting that MYC inversely modulates cell cycle and circadian clock genes.

Bibliographic Details
Main Authors: Anton Shostak, Bianca Ruppert, Nati Ha, Philipp Bruns, Umut H. Toprak, ICGC MMML-Seq Project, Roland Eils, Matthias Schlesner, Axel Diernfellner, Michael Brunner
Format: Article
Language:English
Published: Nature Publishing Group 2016-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11807

Internet

https://doi.org/10.1038/ncomms11807

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