Altered B cell homeostasis and toll-like receptor 9-driven response in type 1 diabetes carriers of the C1858T PTPN22 allelic variant: implications in the disease pathogenesis.

Altered B cell homeostasis and toll-like receptor 9-driven response in type 1 diabetes carriers of the C1858T PTPN22 allelic variant: implications in the disease pathogenesis.

Type 1 diabetes is an autoimmune disease caused by the destruction of pancreatic beta cells by autoreactive T cells. Among the genetic variants associated with type 1 diabetes, the C1858T (Lyp) polymorphism of the protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene alters the function of...

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Bibliographic Details
Main Authors: Elena Gianchecchi, Antonino Crinò, Ezio Giorda, Rosa Luciano, Valentina Perri, Anna Lo Russo, Marco Cappa, M Manuela Rosado, Alessandra Fierabracci
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4205012?pdf=render

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http://europepmc.org/articles/PMC4205012?pdf=render

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