DeepNEU: Artificially Induced Stem Cell (aiPSC) and Differentiated Skeletal Muscle Cell (aiSkMC) Simulations of Infantile Onset POMPE Disease (IOPD) for Potential Biomarker Identification and Drug Discovery

DeepNEU: Artificially Induced Stem Cell (aiPSC) and Differentiated Skeletal Muscle Cell (aiSkMC) Simulations of Infantile Onset POMPE Disease (IOPD) for Potential Biomarker Identification and Drug Discovery

Infantile onset Pompe disease (IOPD) is a rare and lethal genetic disorder caused by the deletion of the acid alpha-glucosidase (GAA) gene. This gene encodes an essential lysosomal enzyme that converts glycogen to glucose. While enzyme replacement therapy helps some, our understanding of disease pat...

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Bibliographic Details
Main Authors: Sally Esmail, Wayne R. Danter
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
iPSC
IOPD
deep machine learning
recurrent neural networks (RNN)
cognitive maps (CM)
support vector machines (SVM)
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00325/full

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https://www.frontiersin.org/article/10.3389/fcell.2019.00325/full

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