Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives

Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives

The study presented here aimed at identifying a new class of compounds acting against Leishmania parasites, the causative agent of Leishmaniasis. For this purpose, the thioether derivatives of our in-house library have been evaluated in whole-cell screening assays in order to determine their in vitr...

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Bibliographic Details
Main Authors: Francesco Saccoliti, Gabriella Angiulli, Giovanni Pupo, Luca Pescatori, Valentina Noemi Madia, Antonella Messore, Gianni Colotti, Annarita Fiorillo, Luigi Scipione, Marina Gramiccia, Trentina Di Muccio, Roberto Di Santo, Roberta Costi, Andrea Ilari
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Diaryl sulfide derivatives
Leishmania infantum
trypanothione reductase
trypanothione reductase inhibition
X-ray crystal structure
Online Access:http://dx.doi.org/10.1080/14756366.2016.1250755

Internet

http://dx.doi.org/10.1080/14756366.2016.1250755

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