Functional inhibition of heat shock protein 70 by VER‐155008 suppresses pleural mesothelioma cell proliferation via an autophagy mechanism

Functional inhibition of heat shock protein 70 by VER‐155008 suppresses pleural mesothelioma cell proliferation via an autophagy mechanism

Abstract Background: Pleural mesothelioma, a devastating asbestos‐associated malignancy, urgently requires a novel effective therapy. Heat shock protein 70 (HSP70), which is synthesized in the cell response to protein damage, is expected to be a new target for antitumor treatment. In addition to its...

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Bibliographic Details
Main Authors: Kosuke Sakai, Maya Inoue, Shintaro Mikami, Hiroaki Nishimura, Yoshiki Kuwabara, Akitoshi Kojima, Maiko Toda, Yumiko Ogawa‐Kobayashi, Satoshi Kikuchi, Yusuke Hirata, Yuriko Mikami‐Saito, Hiroyuki Kyoyama, Gaku Moriyama, Michio Shiibashi, Masahiro Seike, Akihiko Gemma, Kazutsugu Uematsu
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Thoracic Cancer
Subjects:
Gefitinib
heat shock protein 70
macroautophagy
pleural mesothelioma
VER‐155008
Online Access:https://doi.org/10.1111/1759-7714.13784

Internet

https://doi.org/10.1111/1759-7714.13784

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