1,2,4-Oxadiazole/2-Imidazoline Hybrids: Multi-target-directed Compounds for the Treatment of Infectious Diseases and Cancer

1,2,4-Oxadiazole/2-Imidazoline Hybrids: Multi-target-directed Compounds for the Treatment of Infectious Diseases and Cancer

Replacement of amide moiety with the 1,2,4-oxadiazole core in the scaffold of recently reported efflux pump inhibitors afforded a novel series of oxadiazole/2-imidazoline hybrids. The latter compounds exhibited promising antibacterial activity on both Gram-positive (<i>Staphylococcus aureus<...

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Bibliographic Details
Main Authors: Anton Shetnev, Sergey Baykov, Stanislav Kalinin, Alexandra Belova, Vladimir Sharoyko, Anton Rozhkov, Lev Zelenkov, Marina Tarasenko, Evgeny Sadykov, Mikhail Korsakov, Mikhail Krasavin
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
1,2,4-oxadiazole
2-imidazolines
antibacterial
cytotoxicity
MAO inhibition
Online Access:https://www.mdpi.com/1422-0067/20/7/1699

Internet

https://www.mdpi.com/1422-0067/20/7/1699

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