Modification of DNA structure by reactive nitrogen species as a result of 2-methoxyestradiol–induced neuronal nitric oxide synthase uncoupling in metastatic osteosarcoma cells

Modification of DNA structure by reactive nitrogen species as a result of 2-methoxyestradiol–induced neuronal nitric oxide synthase uncoupling in metastatic osteosarcoma cells

2-methoxyestradiol (2-ME) is a physiological anticancer compound, metabolite of 17β-estradiol. Previously, our group evidenced that from mechanistic point of view one of anticancer mechanisms of action of 2-ME is specific induction and nuclear hijacking of neuronal nitric oxide synthase (nNOS), resu...

Full description

Bibliographic Details
Main Authors: Magdalena Gorska-Ponikowska, Agata Ploska, Dagmara Jacewicz, Michal Szkatula, Giampaolo Barone, Giosuè Lo Bosco, Fabrizio Lo Celso, Aleksandra M Dabrowska, Alicja Kuban-Jankowska, Monika Gorzynik-Debicka, Narcyz Knap, Lech Chmurzynski, Lawrence Wawrzyniec Dobrucki, Leszek Kalinowski, Michal Wozniak
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720302366

Internet

http://www.sciencedirect.com/science/article/pii/S2213231720302366

Similar Items