Both intra and inter-domain interactions define the intrinsic dynamics and allosteric mechanism in DNMT1s

Both intra and inter-domain interactions define the intrinsic dynamics and allosteric mechanism in DNMT1s

DNA methyltransferase 1 (DNMT1), a large multidomain enzyme, is believed to be involved in the passive transmission of genomic methylation patterns via methylation maintenance. Yet, the molecular mechanism of interaction networks underlying DNMT1 structures, dynamics, and its biological significance...

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Bibliographic Details
Main Authors: Zhongjie Liang, Yu Zhu, Jie Long, Fei Ye, Guang Hu
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Epigenetic enzymes
Elastic network models
Protein structure networks
Domain motions
Allosteric sites
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037019304714

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http://www.sciencedirect.com/science/article/pii/S2001037019304714

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