Genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention [version 1; peer review: 2 approved]

Genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention [version 1; peer review: 2 approved]

Vascular tumors are neoplasms of endothelial cells, a significant number of which present in childhood. Recent studies have examined the mutational landscape of many subtypes of vascular tumors, identifying mutations primarily within the Ras–mitogen-activated protein kinase (MAPK) pathway and provid...

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Main Authors: Shayan Cheraghlou, Young Lim, Keith Choate
Format: Article
Language:English
Published: F1000 Research Ltd 2019-04-01
Series:F1000Research
Online Access:https://f1000research.com/articles/8-590/v1
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spelling doaj-dde26c36e55f4f67bfd5c7ea593f7bbe2020-11-25T03:29:38ZengF1000 Research LtdF1000Research2046-14022019-04-01810.12688/f1000research.16160.117648Genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention [version 1; peer review: 2 approved]Shayan Cheraghlou0Young Lim1Keith Choate2Department of Dermatology, Yale School of Medicine, New Haven, CT, USADepartment of Dermatology, Yale School of Medicine, New Haven, CT, USADepartment of Dermatology, Yale School of Medicine, New Haven, CT, USAVascular tumors are neoplasms of endothelial cells, a significant number of which present in childhood. Recent studies have examined the mutational landscape of many subtypes of vascular tumors, identifying mutations primarily within the Ras–mitogen-activated protein kinase (MAPK) pathway and providing a unique opportunity to consider targeted therapeutics. This review will summarize the current understanding of childhood vascular tumor pathobiology.https://f1000research.com/articles/8-590/v1
collection DOAJ
language English
format Article
sources DOAJ
author Shayan Cheraghlou
Young Lim
Keith Choate
spellingShingle Shayan Cheraghlou
Young Lim
Keith Choate
Genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention [version 1; peer review: 2 approved]
F1000Research
author_facet Shayan Cheraghlou
Young Lim
Keith Choate
author_sort Shayan Cheraghlou
title Genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention [version 1; peer review: 2 approved]
title_short Genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention [version 1; peer review: 2 approved]
title_full Genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention [version 1; peer review: 2 approved]
title_fullStr Genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention [version 1; peer review: 2 approved]
title_full_unstemmed Genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention [version 1; peer review: 2 approved]
title_sort genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention [version 1; peer review: 2 approved]
publisher F1000 Research Ltd
series F1000Research
issn 2046-1402
publishDate 2019-04-01
description Vascular tumors are neoplasms of endothelial cells, a significant number of which present in childhood. Recent studies have examined the mutational landscape of many subtypes of vascular tumors, identifying mutations primarily within the Ras–mitogen-activated protein kinase (MAPK) pathway and providing a unique opportunity to consider targeted therapeutics. This review will summarize the current understanding of childhood vascular tumor pathobiology.
url https://f1000research.com/articles/8-590/v1
work_keys_str_mv AT shayancheraghlou geneticinvestigationofchildhoodvasculartumorbiologyrevealspathwaysfortherapeuticinterventionversion1peerreview2approved
AT younglim geneticinvestigationofchildhoodvasculartumorbiologyrevealspathwaysfortherapeuticinterventionversion1peerreview2approved
AT keithchoate geneticinvestigationofchildhoodvasculartumorbiologyrevealspathwaysfortherapeuticinterventionversion1peerreview2approved
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