Bacterial Flora Play Important Roles in Acute Dextran Sulphate Sodium-Induced Colitis But Are Not Involved in Gal-3 Dependent Modulation of Colon Inflammation

Bacterial Flora Play Important Roles in Acute Dextran Sulphate Sodium-Induced Colitis But Are Not Involved in Gal-3 Dependent Modulation of Colon Inflammation

An altered immune response to normal gut microflora is important for the pathogenesis of ulcerative colitis (UC). Galectin- 3 (Gal-3) is an endogenous lectin that plays an important pro-inflammatory role in the induction phase of acute colitis by promoting activation of the NLRP3 infl ammasome and p...

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Bibliographic Details
Main Authors: Markovic Bojana Simovic, Milosavljevic Neda, Arsenijevic Aleksandar, Gazdic Marina, Lukic Miodrag L., Volarevic Vladislav
Format: Article
Language:English
Published: Sciendo 2017-10-01
Series:Serbian Journal of Experimental and Clinical Research
Subjects:
acute dss-induced colitis
microflora
gal-3
Online Access:https://doi.org/10.1515/sjecr-2017-0022

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