Molecular Basis of Ubiquitination Catalyzed by the Bacterial Transglutaminase MavC

Molecular Basis of Ubiquitination Catalyzed by the Bacterial Transglutaminase MavC

Abstract The Legionella pneumophila effector MavC is a transglutaminase that carries out atypical ubiquitination of the host ubiquitin (Ub)‐conjugation enzyme UBE2N by catalyzing the formation of an isopeptide bond between Gln40Ub and Lys92UBE2N, which leads to inhibition of signaling in the NF‐κB p...

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Bibliographic Details
Main Authors: Hongxin Guan, Jiaqi Fu, Ting Yu, Zhao‐Xi Wang, Ninghai Gan, Yini Huang, Vanja Perčulija, Yu Li, Zhao‐Qing Luo, Songying Ouyang
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:Advanced Science
Subjects:
deamidase
effectors
Legionella pneumophila
NF‐κB
transglutamination
Online Access:https://doi.org/10.1002/advs.202000871

Internet

https://doi.org/10.1002/advs.202000871

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