TET2 and DNMT3A mutations and exceptional response to 4′-thio-2′-deoxycytidine in human solid tumor models

TET2 and DNMT3A mutations and exceptional response to 4′-thio-2′-deoxycytidine in human solid tumor models

Abstract Background Challenges remain on the selection of patients who potentially respond to a class of drugs that target epigenetics for cancer treatment. This study aims to investigate TET2/DNMT3A mutations and antitumor activity of a novel epigenetic agent in multiple human cancer cell lines and...

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Bibliographic Details
Main Authors: Sherry X. Yang, Melinda Hollingshead, Larry Rubinstein, Dat Nguyen, Angelo B. A. Larenjeira, Robert J. Kinders, Michael Difilippantonio, James H. Doroshow
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Hematology & Oncology
Subjects:
DNMT3A and TET2 mutations
NCI-H23 cells
p21
4′-thio-2′-deoxycytidine (T-dCyd)
Whole exome sequencing
Xenograft tumors
Online Access:https://doi.org/10.1186/s13045-021-01091-5

Internet

https://doi.org/10.1186/s13045-021-01091-5

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