Acetic Acid-Catalyzed Formation of N-Phenylphthalimide from Phthalanilic Acid: A Computational Study of the Mechanism

Acetic Acid-Catalyzed Formation of N-Phenylphthalimide from Phthalanilic Acid: A Computational Study of the Mechanism

In glacial acetic acid, phthalanilic acid and its monosubstituents are known to be converted to the corresponding phthalimides in relatively good yields. In this study, we computationally investigated the experimentally proposed two-step (addition-elimination or cyclization-dehydration) mechanism at...

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Bibliographic Details
Main Authors: Ohgi Takahashi, Ryota Kirikoshi, Noriyoshi Manabe
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:International Journal of Molecular Sciences
Subjects:
phthalanilic acid
intramolecular cyclization
N-phenylphthalimide
acetic acid catalysis
computational chemistry
double proton transfer
concerted bond reorganization
Online Access:http://www.mdpi.com/1422-0067/16/6/12174

Internet

http://www.mdpi.com/1422-0067/16/6/12174

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