Identification of Potential Chemical Substrates as Fuel for Hypoxic Tumors That May Be Linked to Invadopodium Formation in Hypoxia-Induced MDA-MB-231 Breast-Cancer Cell Line

Identification of Potential Chemical Substrates as Fuel for Hypoxic Tumors That May Be Linked to Invadopodium Formation in Hypoxia-Induced MDA-MB-231 Breast-Cancer Cell Line

Hypoxia plays a significant role in solid tumors by the increased expression of hypoxia-inducible factor-1α (HIF-1α), which is known to promote cancer invasion and metastasis. Cancer-cell invasion dynamically begins with the degradation of the extracellular matrix (ECM) via invadopodia formation. Th...

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Bibliographic Details
Main Authors: Hamad Ali Hamad, Hamid Hammad Enezei, Anmar Alrawas, Noraina Muhamad Zakuan, Nurul Akmaryanti Abdullah, Yoke Kqueen Cheah, Nur Fariesha Md Hashim
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Molecules
Subjects:
cancer invasion
invadopodia
ECM
hypoxia
HIF-1α
phenotype microarray
Online Access:https://www.mdpi.com/1420-3049/25/17/3876

Internet

https://www.mdpi.com/1420-3049/25/17/3876

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