The first quarter of the C-terminal domain of Abelson regulates the WAVE regulatory complex and Enabled in axon guidance

Abstract Background Abelson tyrosine kinase (Abl) plays a key role in axon guidance in linking guidance receptors to actin dynamics. The long C-terminal domain (CTD) of Drosophila Abl is important for this role, and previous work identified the ‘first quarter’ (1Q) of the CTD as essential. Here, we...

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Bibliographic Details
Main Authors: Han Sian Joshua Cheong, Mark Nona, Samantha Barbara Guerra, Mark Francis VanBerkum
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Neural Development
Online Access:http://link.springer.com/article/10.1186/s13064-020-00144-8