Matrine attenuates endoplasmic reticulum stress and mitochondrion dysfunction in nonalcoholic fatty liver disease by regulating SERCA pathway

Matrine attenuates endoplasmic reticulum stress and mitochondrion dysfunction in nonalcoholic fatty liver disease by regulating SERCA pathway

Abstract Background Endoplasmic reticulum (ER) stress, which can promote lipid metabolism disorders and steatohepatitis, contributes significantly to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Calcium (Ca2+) homeostasis is considered to play a key role in ER stress. Matrine (Mat)...

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Bibliographic Details
Main Authors: Xiaobo Gao, Shun Guo, Song Zhang, An Liu, Lei Shi, Yan Zhang
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Journal of Translational Medicine
Subjects:
Matrine
ER stress
Ca2+ homeostasis
Mitochondrion dysfunction
Nonalcoholic fatty liver disease
Online Access:http://link.springer.com/article/10.1186/s12967-018-1685-2

Internet

http://link.springer.com/article/10.1186/s12967-018-1685-2

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