Novel N,N-di-alkylnaphthoimidazolium derivative of β-lapachone impaired Trypanosoma cruzi mitochondrial electron transport system

Novel N,N-di-alkylnaphthoimidazolium derivative of β-lapachone impaired Trypanosoma cruzi mitochondrial electron transport system

Trypanosoma cruzi is a protozoan parasite that causes Chagas disease, a neglected tropical disease that is endemic in Latin America and spreading worldwide due to globalization. The current treatments are based on benznidazole and nifurtimox; however, these drugs have important limitations and limit...

Full description

Bibliographic Details
Main Authors: Ana Cristina S. Bombaça, Leonardo A. Silva, Otávio Augusto Chaves, Lorrainy S. da Silva, Juliana M.C. Barbosa, Ari M. da Silva, Aurélio B.B. Ferreira, Rubem F.S. Menna-Barreto
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Trypanosoma cruzi
Chemotherapy
Naphthoimidazoles
Mitochondria
Oxidative stress
Succinate dehydrogenase
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220313792

Internet

http://www.sciencedirect.com/science/article/pii/S0753332220313792

Similar Items