Development of a Supercritical Fluid Chromatography-Tandem Mass Spectrometry Method for the Determination of Azacitidine in Rat Plasma and Its Application to a Bioavailability Study

Development of a Supercritical Fluid Chromatography-Tandem Mass Spectrometry Method for the Determination of Azacitidine in Rat Plasma and Its Application to a Bioavailability Study

Azacitidine is widely used for the treatment of myelodysplastic syndromes (MDS) and acute myelogenous leukaemia (AML). The analysis of azacitidine in biological samples is subject to interference by endogenous compounds. Previously reported high-performance liquid chromatography/tandem mass spectro...

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Bibliographic Details
Main Authors: Dongpo Li, Tianhong Zhang, Longfa Kou, Youxi Zhang, Jin Sun, Zhonggui He
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:Molecules
Subjects:
azacitidine
SFC-MS/MS
rat plasma
intravenous
Online Access:http://www.mdpi.com/1420-3049/19/1/342

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http://www.mdpi.com/1420-3049/19/1/342

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