Overexpression of miR-1 in the heart attenuates hippocampal synaptic vesicle exocytosis by the posttranscriptional regulation of SNAP-25 through the transportation of exosomes

Overexpression of miR-1 in the heart attenuates hippocampal synaptic vesicle exocytosis by the posttranscriptional regulation of SNAP-25 through the transportation of exosomes

Abstract Background The link between cardiac diseases and cognitive deterioration has been accepted from the concept of “cardiogenic dementia”, which was proposed in the late 1970s. However, the molecular mechanism is unclarified. Methods The two animal models used in this study were cardiac-specifi...

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Bibliographic Details
Main Authors: Ming-Jing Duan, Mei-Ling Yan, Qin Wang, Meng Mao, Dan Su, Lin-Lin Sun, Ke-Xin Li, Yang Qu, Qiang Sun, Xin-Yu Zhang, Si-Yu Huang, Ji-Chao Ma, Tao Ban, Jing Ai
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Cell Communication and Signaling
Subjects:
Heart
Hippocampus
Synaptic vesicle exocytosis
microRNA-1
SNAP-25
Online Access:http://link.springer.com/article/10.1186/s12964-018-0303-5

Internet

http://link.springer.com/article/10.1186/s12964-018-0303-5

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