Lineage-Specific Proteomic Signatures in the Mycobacterium tuberculosis Complex Reveal Differential Abundance of Proteins Involved in Virulence, DNA Repair, CRISPR-Cas, Bioenergetics and Lipid Metabolism

Lineage-Specific Proteomic Signatures in the Mycobacterium tuberculosis Complex Reveal Differential Abundance of Proteins Involved in Virulence, DNA Repair, CRISPR-Cas, Bioenergetics and Lipid Metabolism

Despite the discovery of the tubercle bacillus more than 130 years ago, its physiology and the mechanisms of virulence are still not fully understood. A comprehensive analysis of the proteomes of members of the human-adapted Mycobacterium tuberculosis complex (MTBC) lineages 3, 4, 5, and 7 was condu...

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Bibliographic Details
Main Authors: Solomon Abebe Yimer, Shewit Kalayou, Håvard Homberset, Alemayehu Godana Birhanu, Tahira Riaz, Ephrem Debebe Zegeye, Timo Lutter, Markos Abebe, Carol Holm-Hansen, Abraham Aseffa, Tone Tønjum
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Microbiology
Subjects:
Mycobacterium tuberculosis
lineage 7
proteomics
DNA repair
ESX-3 secretion system
virulence
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.550760/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.550760/full

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