Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4.

Spatio-temporal activation of Rho GTPases is essential for their function in a variety of biological processes and is achieved in part by regulating the localization of their activators, the Rho guanine nucleotide exchange factors (RhoGEFs). In this study, we provide the first characterization of th...

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Bibliographic Details
Main Authors: Natalia Mitin, Kent L Rossman, Channing J Der
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3404065?pdf=render