TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target

TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target

Depletion of tribbles pseudokinase 3 (TRIB3) is known to suppress the expression of several tumor-promoting factors, including EGFR. Here, the authors show that TRIB3 interacts with EGFR and regulates its stability and activity, and perturbing EGFR-TRIB3 interaction attenuates NSCLC progression by a...

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Bibliographic Details
Main Authors: Jiao-jiao Yu, Dan-dan Zhou, Xiao-xiao Yang, Bing Cui, Feng-wei Tan, Junjian Wang, Ke Li, Shuang Shang, Cheng Zhang, Xiao-xi Lv, Xiao-wei Zhang, Shan-shan Liu, Jin-mei Yu, Feng Wang, Bo Huang, Fang Hua, Zhuo-Wei Hu
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17385-0

Internet

https://doi.org/10.1038/s41467-020-17385-0

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