Weighting sequence variants based on their annotation increases the power of genome-wide association studies in dairy cattle

Abstract Background Genome-wide association studies (GWAS) are widely used to identify regions of the genome that harbor genetic determinants of quantitative traits. However, the multiple-testing burden from scanning tens of millions of whole-genome sequence variants reduces the power to identify as...

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Bibliographic Details
Main Authors: Zexi Cai, Bernt Guldbrandtsen, Mogens Sandø Lund, Goutam Sahana
Format: Article
Language:deu
Published: BMC 2019-05-01
Series:Genetics Selection Evolution
Online Access:http://link.springer.com/article/10.1186/s12711-019-0463-9