Functional Interactions of Tau Phosphorylation Sites That Mediate Toxicity and Deficient Learning in Drosophila melanogaster

Functional Interactions of Tau Phosphorylation Sites That Mediate Toxicity and Deficient Learning in Drosophila melanogaster

Hyperphosphorylated Tau protein is the main component of the neurofibrillary tangles, characterizing degenerating neurons in Alzheimer’s disease and other Tauopathies. Expression of human Tau protein in Drosophila CNS results in increased toxicity, premature mortality and learning and memory deficit...

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Bibliographic Details
Main Authors: Iason Keramidis, Ergina Vourkou, Katerina Papanikolopoulou, Efthimios M. C. Skoulakis
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Tau
Tau phosphorylation
toxicity
neuronal dysfunction
learning deficits
gatekeeper phosphorylation
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2020.569520/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2020.569520/full

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