The transcription factor FOXL2 mobilizes estrogen signaling to maintain the identity of ovarian granulosa cells

The transcription factor FOXL2 mobilizes estrogen signaling to maintain the identity of ovarian granulosa cells

FOXL2 is a lineage determining transcription factor in the ovary, but its direct targets and modes of action are not fully characterized. In this study, we explore the targets of FOXL2 and five nuclear receptors in murine primary follicular cells. We found that FOXL2 is required for normal gene regu...

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Bibliographic Details
Main Authors: Adrien Georges, David L'Hôte, Anne Laure Todeschini, Aurélie Auguste, Bérangère Legois, Alain Zider, Reiner A Veitia
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-11-01
Series:eLife
Subjects:
ovary
cell identity
transcription factor
FOXL2
estrogen
estrogen receptor
Online Access:https://elifesciences.org/articles/04207

Internet

https://elifesciences.org/articles/04207

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