Cholinergic stimulation prevents the development of autoimmune diabetes: Evidence for the modulation of Th17 effector cells via an IFNgamma-dependent mechanism

Cholinergic stimulation prevents the development of autoimmune diabetes: Evidence for the modulation of Th17 effector cells via an IFNgamma-dependent mechanism

Type I diabetes (T1D) results from T cell-mediated damage of pancreatic β-cells and loss of insulin production. The cholinergic anti-inflammatory pathway represents a physiological link connecting the central nervous and immune systems via vagus nerve, and functions to control the release of proinfl...

Full description

Bibliographic Details
Main Authors: Junu George, Ghada Bashir, Mohammed M Qureshi, Yassir A Mohamed, Jamil Roumanos Azzi, Basel K al-Ramadi, Maria J Fernandez-Cabezudo
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Immunology
Subjects:
Acetylcholine
Th17
IFNg
type I diabetes
Anti-inflammatory pathway
Inhibition of AChE
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00419/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00419/full

Similar Items