Increased light exposure alleviates one form of photoreceptor degeneration marked by elevated calcium in the dark.

Increased light exposure alleviates one form of photoreceptor degeneration marked by elevated calcium in the dark.

BACKGROUND:In one group of gene mutations that cause photoreceptor degeneration in human patients, guanylyl cyclase is overactive in the dark. The ensuing excess opening of cGMP-gated cation channels causes intracellular calcium to rise to toxic levels. The Y99C mutation in guanylate cyclase-activat...

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Bibliographic Details
Main Authors: Xiaoqing Liu, Basil S Pawlyk, Michael Adamian, Elena V Olshevskaya, Alexander M Dizhoor, Clint L Makino, Tiansen Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2793020?pdf=render

Internet

http://europepmc.org/articles/PMC2793020?pdf=render

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