Validated analytical study of the effect of Lycopene on the pharmacokinetics of Paracetamol and Chlorzoxazone in rats

Lycopene was reported to influence some cytochrome P450 enzymes activity. The present study investigates the effect of lycopene on the pharmacokinetics of paracetamol and chlorzoxazone. Lycopene (20 mg/kg) was intra-peritoneally administered to two groups of rats for eight consecutive days and two o...

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Bibliographic Details
Main Authors: Reem Baha-Aldeen Youssef, Marwa Ahmed Fouad*, Asmaa Ahmed El-Zaher
Format: Article
Language:English
Published: Universidade de São Paulo
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
AUC
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100540&lng=en&tlng=en