Deficiency of malate-aspartate shuttle component SLC25A12 induces pulmonary metastasis

Deficiency of malate-aspartate shuttle component SLC25A12 induces pulmonary metastasis

Abstract Background Aspartate biosynthesis and its delivery to the cytosol can be crucial for tumor growth in vivo. However, the impact of intracellular aspartate levels on metastasis has not been studied. We previously described that loss-of-aspartate glutamate carrier 1 (SLC25A12 or AGC1), an impo...

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Bibliographic Details
Main Authors: H. Furkan Alkan, Paul W. Vesely, Hubert Hackl, Johannes Foßelteder, Daniel R. Schmidt, Matthew G. Vander Heiden, Martin Pichler, Gerald Hoefler, Juliane G. Bogner-Strauss
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Cancer & Metabolism
Subjects:
Malate-Aspartate Shuttle
AGC1
Aralar
SLC25A12
Metastasis
Aspartate
Online Access:http://link.springer.com/article/10.1186/s40170-020-00232-7

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http://link.springer.com/article/10.1186/s40170-020-00232-7

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