The Protective Effect of Alpha-Mangostin against Cisplatin-Induced Cell Death in LLC-PK1 Cells is Associated to Mitochondrial Function Preservation

The Protective Effect of Alpha-Mangostin against Cisplatin-Induced Cell Death in LLC-PK1 Cells is Associated to Mitochondrial Function Preservation

Cis-dichlorodiammineplatinum II (CDDP) is a chemotherapeutic agent that induces nephrotoxicity by different mechanisms, including oxidative stress, mitochondrial dysfunction, autophagy, and endoplasmic reticulum stress. This study aimed to evaluate if the protective effects of the antioxidant alpha-...

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Bibliographic Details
Main Authors: Laura María Reyes-Fermín, Sabino Hazael Avila-Rojas, Omar Emiliano Aparicio-Trejo, Edilia Tapia, Isabel Rivero, José Pedraza-Chaverri
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Antioxidants
Subjects:
alpha-mangostin
cisplatin
nephrotoxicity
mitochondria function
mitophagy
Online Access:https://www.mdpi.com/2076-3921/8/5/133

Internet

https://www.mdpi.com/2076-3921/8/5/133

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