Affinity and avidity models in autoimmune disease

• Main Author: James Peterson
• Format: Article
• Language: English
• Published: American Institute of Mathematical Sciences 2018-04-01
• Series: AIMS Allergy and Immunology
• Subjects: T cell models; cubic ternary complex receptor; ligand interactions; immunological kinapses and synapses; self versus non-self computations; affinity; efficacy and avidity models
• Online Access: http://www.aimspress.com/Allergy/article/1925/fulltext.html
• ISSN: 2575-615X

In this work, we develop a theoretical model of affinity and avidity in the immune system.The model is based on an extension of the Cubic Ternary Complex (CTC) model of receptor - ligandinteractions to the immunological synapse setting. We use the resulting equation to study how lysiscan occur for a cell exhibiting only self proteins. This general affinity model gives a nice quantitativetool which can be used to explore a nonlinear model of how a T Cell can have a productive interactionwith a MHC-I complex even though the encapsulated peptide fragment is a self protein. The modelbuilt will allow the creation of even more general autoimmune models within the framework of B andT Cell differentiation via cytokine signalling families.