Size does matter: overcoming the adeno-associated virus packaging limit
<p>Abstract</p> <p>Recombinant adeno-associated virus (rAAV) vectors mediate long-term gene transfer without any known toxicity. The primary limitation of rAAV has been the small size of the virion (20 nm), which only permits the packaging of 4.7 kilobases (kb) of exogenous DNA, in...
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| Format: | Article |
| Language: | English |
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BMC
2000-07-01
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| Series: | Respiratory Research |
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| Online Access: | http://respiratory-research.com/content/1/1/016 |