Aging and CaMKII alter intracellular Ca2+ transients and heart rhythm in Drosophila melanogaster.

Aging and CaMKII alter intracellular Ca2+ transients and heart rhythm in Drosophila melanogaster.

Aging is associated to disrupted contractility and rhythmicity, among other cardiovascular alterations. Drosophila melanogaster shows a pattern of aging similar to human beings and recapitulates the arrhythmogenic conditions found in the human heart. Moreover, the kinase CaMKII has been characterize...

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Bibliographic Details
Main Authors: Manuela Santalla, Carlos A Valverde, Ezequiel Harnichar, Ezequiel Lacunza, Javier Aguilar-Fuentes, Alicia Mattiazzi, Paola Ferrero
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4087024?pdf=render

Internet

http://europepmc.org/articles/PMC4087024?pdf=render

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