Antimelanoma activities of chimeric thiazole–androstenone derivatives

Antimelanoma activities of chimeric thiazole–androstenone derivatives

The discovery of chimeric anti-melanoma agents is reported. These molecules are potent growth suppressors of melanoma cells in vitro with growth inhibition of 50% (GI50) values as low as 1.32 µM. Compounds were more toxic to melanoma cells in vitro than commonly used anti-melanoma agent dacarbazine...

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Bibliographic Details
Main Authors: Steven A. Chambers, Mathew Newman, Melissa M. Frangie, Alena V. Savenka, Alexei. G. Basnakian, Mohammad A. Alam
Format: Article
Language:English
Published: The Royal Society 2021-08-01
Series:Royal Society Open Science
Subjects:
melanoma
thiazole
androstenone
flow cytometry
apoptosis
TUNEL assay
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsos.210395

Internet

https://royalsocietypublishing.org/doi/10.1098/rsos.210395

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