ABCG5 and ABCG8 require MDR2 for secretion of cholesterol into bile

ABCG5 and ABCG8 require MDR2 for secretion of cholesterol into bile

The major pathway for the removal of cholesterol from the body is via secretion into the bile. Three members of the ATP binding cassette (ABC) family, ABCG5 (G5), ABCG8 (G8), and ABCB4 (MDR2), are required for the efficient biliary export of sterols. Here, we examined the interdependence of these th...

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Bibliographic Details
Main Authors: Silvia Langheim, Liqing Yu, Klaus von Bergmann, Dieter Lütjohann, Fang Xu, Helen H. Hobbs, Jonathan C. Cohen
Format: Article
Language:English
Published: Elsevier 2005-08-01
Series:Journal of Lipid Research
Subjects:
ATP binding cassette transporters G5 and G8
ATP binding cassette transporter B4
sitosterol
campesterol
cholesterol absorption
bile acid
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520329722

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http://www.sciencedirect.com/science/article/pii/S0022227520329722

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