A Novel Multi-Target Small Molecule, LCC-09, Inhibits Stemness and Therapy-Resistant Phenotypes of Glioblastoma Cells by Increasing miR-34a and Deregulating the DRD4/Akt/mTOR Signaling Axis

A Novel Multi-Target Small Molecule, LCC-09, Inhibits Stemness and Therapy-Resistant Phenotypes of Glioblastoma Cells by Increasing miR-34a and Deregulating the DRD4/Akt/mTOR Signaling Axis

The management of glioblastomas (GBMs) is challenged by the development of therapeutic resistance and early disease recurrence, despite multi-modal therapy. This may be attributed to the presence of glioma stem cells (GSCs) which are known to survive radio- and chemotherapy, by circumventing death s...

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Bibliographic Details
Main Authors: Ya-Ting Wen, Alexander TH Wu, Oluwaseun Adebayo Bamodu, Li Wei, Chien-Min Lin, Yun Yen, Tsu-Yi Chao, Debabrata Mukhopadhyay, Michael Hsiao, Hsu-Shan Huang
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
lcc-09
glioblastoma (gbm)
glioma stem cells
stemness
temozolomide resistance
dopamine receptor
mir-34a
maintenance therapy
adjuvant therapy
multi-target therapeutics
Online Access:https://www.mdpi.com/2072-6694/11/10/1442

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https://www.mdpi.com/2072-6694/11/10/1442

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