Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes

Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes

Heme (iron-protoporphyrin IX) is an essential co-factor involved in multiple biological processes: oxygen transport and storage, electron transfer, drug and steroid metabolism, signal transduction, and micro RNA processing. However, excess free-heme is highly toxic due to its ability to promote oxid...

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Bibliographic Details
Main Authors: Deborah eChiabrando, Francesca eVinchi, Veronica eFiorito, Sonia eMercurio, Emanuela eTolosano
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Pharmacology
Subjects:
Hemopexin
ABCG2
HO-1
FLVCR1
FLVCR2
HCP1/PCFT
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00061/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00061/full

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