Identification of Loop D Domain Amino Acids in the Human Aquaporin-1 Channel Involved in Activation of the Ionic Conductance and Inhibition by AqB011

Identification of Loop D Domain Amino Acids in the Human Aquaporin-1 Channel Involved in Activation of the Ionic Conductance and Inhibition by AqB011

Aquaporins are integral proteins that facilitate the transmembrane transport of water and small solutes. In addition to enabling water flux, mammalian Aquaporin-1 (AQP1) channels activated by cyclic GMP can carry non-selective monovalent cation currents, selectively blocked by arylsulfonamide compou...

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Bibliographic Details
Main Authors: Mohamad Kourghi, Michael L. De Ieso, Saeed Nourmohammadi, Jinxin V. Pei, Andrea J. Yool
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Chemistry
Subjects:
major intrinsic protein
MIP
AQP1
water channel
non-selective cation channel
cyclic GMP
Online Access:http://journal.frontiersin.org/article/10.3389/fchem.2018.00142/full

Internet

http://journal.frontiersin.org/article/10.3389/fchem.2018.00142/full

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