Antibody Fab‐Fc properties outperform titer in predictive models of SIV vaccine‐induced protection

Antibody Fab‐Fc properties outperform titer in predictive models of SIV vaccine‐induced protection

Abstract Characterizing the antigen‐binding and innate immune‐recruiting properties of the humoral response offers the chance to obtain deeper insights into mechanisms of protection than revealed by measuring only overall antibody titer. Here, a high‐throughput, multiplexed Fab‐Fc Array was employed...

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Bibliographic Details
Main Authors: Srivamshi Pittala, Kenneth Bagley, Jennifer A Schwartz, Eric P Brown, Joshua A Weiner, Ilia J Prado, Wenlei Zhang, Rong Xu, Ayuko Ota‐Setlik, Ranajit Pal, Xiaoying Shen, Charles Beck, Guido Ferrari, George K Lewis, Celia C LaBranche, David C Montefiori, Georgia D Tomaras, Galit Alter, Mario Roederer, Timothy R Fouts, Margaret E Ackerman, Chris Bailey‐Kellogg
Format: Article
Language:English
Published: Wiley 2019-05-01
Series:Molecular Systems Biology
Subjects:
antibody effector function
biomarker identification
HIV
protection modeling
systems serology
Online Access:https://doi.org/10.15252/msb.20188747

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