Variable-order sequence modeling improves bacterial strain discrimination for Ion Torrent DNA reads

Variable-order sequence modeling improves bacterial strain discrimination for Ion Torrent DNA reads

Abstract Background Genome sequencing provides a powerful tool for pathogen detection and can help resolve outbreaks that pose public safety and health risks. Mapping of DNA reads to genomes plays a fundamental role in this approach, where accurate alignment and classification of sequencing data is...

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Bibliographic Details
Main Authors: Thomas M. Poulsen, Martin Frith
Format: Article
Language:English
Published: BMC 2017-06-01
Series:BMC Bioinformatics
Subjects:
Sequence alignment
Higher order
HMM
Ion Torrent
Pathogen detection
Online Access:http://link.springer.com/article/10.1186/s12859-017-1710-0

Internet

http://link.springer.com/article/10.1186/s12859-017-1710-0

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