Norepinephrine can Act via α2-Adrenoceptors to Reduce the Hyper-excitability of Spinal Dorsal Horn Neurons Following Chronic Nerve Injury

Norepinephrine can Act via α2-Adrenoceptors to Reduce the Hyper-excitability of Spinal Dorsal Horn Neurons Following Chronic Nerve Injury

Rats display behavioral signs of neuropathic pain lasting for months in the chronic constriction injury (CCI) model. During intrathecal anesthesia, the administered drugs mainly diffuse directly into the superficial neurons in the spinal dorsal horn. This study aimed to investigate the effect of bat...

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Bibliographic Details
Main Authors: Lu-Yang Jiang, Shu-Ren Li, Fei-Yue Zhao, David Spanswick, Mao-Tsun Lin
Format: Article
Language:English
Published: Elsevier 2010-06-01
Series:Journal of the Formosan Medical Association
Subjects:
α2-adrenoceptors
allodynia
neuropathic pain
norepinephrine
spinal dorsal horn
Online Access:http://www.sciencedirect.com/science/article/pii/S0929664610600757

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http://www.sciencedirect.com/science/article/pii/S0929664610600757

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