KDM5C is transcriptionally regulated by BRD4 and promotes castration-resistance prostate cancer cell proliferation by repressing PTEN

KDM5C is transcriptionally regulated by BRD4 and promotes castration-resistance prostate cancer cell proliferation by repressing PTEN

Prostate cancer (PCa) is one of the leading causes of cancer-related death worldwide, and it is almost incurable once it has developed into castration-resistance prostate cancer (CRPC). However, the mechanisms underlying the oncogenesis of PCa and CRPC remain elusive. Lysine-specific histone demethy...

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Bibliographic Details
Main Authors: Zhe Hong, Gang Wu, Zhen-Dong Xiang, Cheng-Dang Xu, Sheng-Song Huang, Chao Li, Lei Shi, Deng-Long Wu
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Lysine-specific histone demethylase 5C (KDM5C)
Bromo-domain containing protein 4 (BRD4)
Phosphatase and tensin homolog (PTEN)
Cell proliferation
Castration-resistance prostate cancer (CRPC)
Online Access:http://www.sciencedirect.com/science/article/pii/S075333221930633X

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http://www.sciencedirect.com/science/article/pii/S075333221930633X

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